Cryopreserved Platelets Retain Agonist Responsiveness and Support for Factor VIII Function
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چکیده
منابع مشابه
Factor VIII-induced superaggregation of human platelets.
High concentrations of bovine factor VIII cause clumping of platelets into a few very large aggregates. This response is termed superaggregation. It is distinct from factor-VIII-induced agglutination but is also independent of both extracellular calcium ions and platelet energy metabolism. Neither agglutinating lectins nor aggregating agents, including thrombin, ADP, the ionophore A23187, and U...
متن کاملFactor VIII structure and function.
Factor VIII, a non-covalent heterodimer comprised of a heavy chain (A1-A2-B domains) and light chain (A3-C1-C2 domains), circulates as an inactive procofactor in complex with von Willebrand factor. Metal ions are critical to the integrity of factor VIII, with Cu and Ca ions stabilizing the heterodimer and generating the active conformation, respectively. Activation of factor VIII catalyzed by t...
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Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...
متن کاملRelationships between Spleen , Platelets and Factor VIII Levels
P HYSIOLOGIC ELEVATIONS of Factor VIII occur in health and disease and are either transient or sustained (Table 1 ).l.17 The same stressful stimuli that produce transient increases in Factor VIII, notably adrenalin or exercise, also produce transient elevations of circulating platelets.182#{176} Since the platelet response is abolished by splenectomy, in the present work it was of interest to c...
متن کاملThe factor VIII complex: structure and function.
Normal human plasma contains a complex of two proteins that are important in hemostasis and coagulation. The factor VIII procoagulant protein (antihemophilic factor) and the factor VIII-related protein (von Willebrand factor) are under separate genetic control, have distinct biochemical properties, and have unique and essential physiologic properties. While the nature of their interaction and t...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2020-143366